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You know, if we knew a little more about Mac programming, this would be a pretty cool app and source code to mess around with. Hiroaki made an Mac application that can potentially allow users to control other programs using your Wiimote.
Called the DarwiinRemote, it's an app that sends and receives data to and from the Wiimote. Currently, the DarwiinRemote can only support single mouse and AppleRemote modes, but Hiroaki is hoping to put a lot of other features in future versions of his work. It requires Mac OS X 10.4 and above and Universal Binary though, so make sure you have those as well before testing this.
Of course, he does remind you that this is called DarwiinRemote v0.1a for a reason. It's new, experimental, and probably unstable, so you'd best use caution when tweaking stuff on it. Be sure to send Hiroaki some love over at his blog as well!
Enjoy checking out this source code, and let's see if Hiroaki's DarwiinRemote v0.1a can bring about an evolution in Wiimote use.